Walden Inversion

Walden Inversion

Walden Inversion

Walden inversion is a chemical reaction that reverses the configuration of a chiral center in a molecule. Walden inversion is also known as optical inversion. The reaction is named after Russian, Latvian, and German chemist Paul Walden who discovered it in 1895.

Since a molecule can form two enantiomers around a chiral centre, the Walden inversion converts the configuration of the molecule from one enantiomeric form to another.

In a SN2 reaction, Walden inversion occurs at a tetrahedral carbon atom wherein the leaving group departs and incoming group attached at the same time (concerted process).

Walden Inversion

Walden inversion can be visualized by imagining an umbrella turned inside-out in a gale.

Walden Inversion See through Umbrella

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