Synthesis of Equilenin

Equilenin, also known as 6,8-didehydroestrone is a naturally occurring steroidal estrogen obtained from the urine of pregnant mares and extensively used for estrogen replacement therapy in postmenopausal women. It's molecular formula is C₁₈H₁₈O₂ having molecular weight 266.33 g/mol. It was the first complex natural product to be fully synthesized by Bachmann and Wilds. It is also synthesized by Johnson.

Synthesis of Equilenin from Compound (A) by Johnson's Synthesis

Johnson synthesize equilenin from compound (A) takes palce in the following steps-

Bachmann's Synthesis of Compound (A)

Bachmann's synthesis of compound (A) takes palce in the following steps-